Evidence map›Paper›PMID 41245842›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025

Early de-escalation of empiric antibiotic therapy in neutropenic fever: a single-center, retrospective study.

Zachary Mostel, Michelle Evans, Douglas Tremblay, Meenakshi Rana, Samantha E Jacobs, John Mascarenhas, Alla Keyzner, Daniel Park, Risa Fuller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zachary MostelDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID https://orcid.org/0000-0003-0077-464X
Michelle EvansDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Douglas TremblayTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Meenakshi RanaDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID https://orcid.org/0000-0001-9366-5359
Samantha E JacobsDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
John MascarenhasTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Alla KeyznerTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID https://orcid.org/0000-0001-6272-8257
Daniel ParkDepartment of Pharmacy, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID https://orcid.org/0000-0002-1940-668X
Risa FullerDivision of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID https://orcid.org/0000-0003-3263-166X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.

Identifiers

PMID41245842
PMCPMC12616562

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.