Evidence map›Paper›PMID 41245835›Full record

ArticleFrontiers in neuroscience2025

Engineered spermidine-secreting

Florance Parweez, Roger Palou, Ruizhen Li, Lanna Kadhim, Heath MacMillan, Mike Tyers, X Johné Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Florance ParweezInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Roger PalouProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Ruizhen LiInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Lanna KadhimInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Heath MacMillanDepartment of Biology and Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Mike TyersProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
X Johné LiuInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The polyamines putrescine, spermidine, and spermine are ubiquitous metabolites synthesized in all cells. The intracellular levels of polyamines, especially spermidine, decrease in aging. Oral spermidine supplementation has been reported to alleviate aspects of aging-related disease in animal models, including decline in learning and memory. The diverse health benefits of spermidine supplementation, often at doses that do not significantly alter spermidine levels of target organs, suggests that exogenous spermidine may have a common site of action, the gastrointestinal (GI) tract. Methods: To directly deliver spermidine to the GI tract with minimum impact on the global spermidine levels, we engineered the probiotic yeast Results: Feeding of newly eclosed flies of the wild-type (w Conclusion: These results demonstrate that

Indexed as

diuretic hormone Dh31D. melanogastergastrointestinal tractgut-brain-axisS. boulardiishort-term memoryspermidine

Identifiers

PMID41245835
PMCPMC12615376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.