Evidence map›Paper›PMID 41245832›Full record

ArticleFrontiers in neuroscience2025

Transcriptomic analysis of identical twins with different onset ages of adrenoleukodystrophy.

Chuhua Fu, Qiuyu Su, Yinglian Chen, Yonghui Zhang, Yan Zhang, Ying Cao, Xinggang Wang, Zhiming Zhen, Chen Liu, Zhao Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chuhua Fu *Department of Neurosurgery, JingMen People's Hospital, Jingchu University of Technology Affiliated JingMen People's Hospital, JingMen, Hubei, China.
Qiuyu Su *Department of Neurology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Yinglian Chen *Center of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Yonghui ZhangCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Yan ZhangCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Ying CaoCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Xinggang WangDepartment of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Zhiming ZhenDepartment of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Chen LiuCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Zhao YangDepartment of Neurology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Changlin YinCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Liang TanCenter of Critical Care Medicine, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the ATP-binding cassette subfamily D member 1 ( Methods: The identification of differentially expressed genes (DEGs), set theory analysis, gene enrichment analysis, and classification statistics of expression trends have been executed to acquire potential candidate genes inducing the onset and severity of ALD in patients. The study cohort comprised eight individuals: two normal children, two pediatric twins with ALD, the twins' mother, their adult uncle with ALD, the twins'grandmother, and one normal adult. Results: Five distinct sets of differentially expressed genes (DEGs) were identified using whole blood samples from a family of identical twins with different onset ages and ABCD1 exon 2 deletions. Then, 39 DEGs of A ∩ B ∩ C - D and A ∩ B - D, as well as 425 DEGs of C ∩ E, were considered as genes relating to the onset and severity of ALD. In particular, C4BPA, TPBG, CEP112, CHST15, SMAD1, IL-26, and Discussion: The information on candidate genes of this study was considered crucial for preliminarily exploring the molecular mechanisms related to the onset and severity of ALD, which offered novel insights and research directions for mitigating and treating the development of ALD.

Indexed as

ABCD1 geneadrenoleukodystrophydifferentially expressed genesidentical twinstranscriptomic analysis

Identifiers

PMID41245832
PMCPMC12615386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.