ArticleFrontiers in bioengineering and biotechnology2025
PRP-loaded hydrogel for rotator cuff repair by promoting osteogenic differentiation and tendon regeneration.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
Objective: Rotator cuff injuries are a common and challenging shoulder joint pathology that significantly impacts shoulder function and quality of life. Current treatments, particularly arthroscopic repair, face high failure rates due to the difficulty of regenerating the native tendon-bone interface. This study aimed to develop and evaluate a platelet-rich plasma-carboxymethyl chitosan-tannic acid composite hydrogel (PRP-CMCS-TA), designed to address these limitations and enhance the repair and regeneration of the tendon-bone interface. Methods: The composite hydrogel was synthesized by creating a CMCS-TA hydrogel via chemical cross-linking, which was then integrated with PRP. Its functionality was assessed through a series of Results: Conclusion: The PRP-CMCS-TA composite hydrogel exhibits good biocompatibility and effectively repairs the tendon-bone interface by promoting osteogenic differentiation and tendon regeneration. This study provides new insights into the application of bioactive materials for rotator cuff injuries and offers a promising strategy for improving the outcomes of rotator cuff repair. Further research and clinical trials are needed to translate these findings into practical applications and to establish the hydrogel as a standard treatment option for rotator cuff injuries.
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