ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2025
Anaeic and tumoic acids, new functionalized fatty acids from marine cyanobacteria, inhibit quorum sensing in
Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Quorum sensing (QS) is the mechanism in which bacteria assess the threshold concentration of small signaling molecules to induce cell survival by overwhelming the host's defenses. It is one of the fundamental mechanisms controlling bacterial mobility, motility, biofilm formation, and virulence. As many clinically resistant strains bypass traditional antimicrobial medications through this pathway, finding new therapeutics that target QS mechanisms is essential to treat these dangerous pathogens. Marine microbes are a promising source of potential therapeutics and have evolved molecules that can modulate disease-relevant signaling pathways, including QS. Compounds of various biosynthetic origin, including lipopeptides, alkaloids, cyclic peptides, and fatty acids have been shown to modulate QS pathways. In the present work, we have described the isolation, structure characterization, and biological evaluation of two new fatty acids, anaeic acid and tumoic acid. Anaeic acid (
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