Evidence map›Paper›PMID 41245593›Full record

ArticleJRSM cardiovascular disease

Troponin at presentation: A key predictor of chronic myocardial impairment post-myocarditis-A prospective cohort study.

Omar Ayyad, Sorel Goland, Nizar Abu Hamdeh, Amir Haim, Ramon Cohen, Alena Kirzhner, Tal Schiller, Zeina Sinnokrot, Firas Besharieh, Mustafa Abu Teer and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Omar AyyadHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Sorel GolandHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Nizar Abu HamdehHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Amir HaimHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Ramon CohenDepartment of Internal Medicine B, Kaplan Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Alena KirzhnerDepartment of Internal Medicine A, Kaplan Medical Center, Rehovot, Israel.
Tal SchillerFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-8378-2903
Zeina SinnokrotDepartment of Diabetes, Endocrinology and Metabolism, Kaplan Medical Center, Rehovot, Israel.
Firas BeshariehHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.ORCID https://orcid.org/0009-0009-7293-3794
Mustafa Abu TeerHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.ORCID https://orcid.org/0009-0007-0018-2288
Majde Abu KhaledHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Gal SellaHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Duha NajajraHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Lail Abu SlemyHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.
Mohammad AlneesHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-5577-8499
Haitham Abu KhadijaHeart Center, Kaplan Medical Center, affiliated with the Hebrew University, Rehovot, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-2336-3125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Myocarditis may lead to persistent myocardial impairment. We evaluated whether admission troponin I and inflammatory biomarkers predict one-year myocardial impairment using global longitudinal strain (GLS) as the reference outcome. Design: Prospective, single-center cohort study (2013-2023); approved by the Kaplan Medical Center Institutional Review Board (KMC-10-0068). Setting: Kaplan Medical Center, Israel. Participants: A total of 115 patients were admitted with myocarditis, defined by ESC criteria. Main outcome measures: Admission biomarkers included troponin I (pg/mL), white blood cells (WBC; × 10 Results: Myocardial impairment occurred in 22.6% (26/115). Median troponin I was higher in impaired versus non-impaired patients (11,517 vs 5918 pg/mL; Conclusions: Admission troponin I provides the strongest predictive value for one-year myocardial impairment in myocarditis, with complementary contributions from WBC, CRP, and LV E/E'. These accessible measures support early risk stratification where advanced imaging is limited.

Indexed as

CRPESRGLSmyocarditisTroponin Iwhite blood cell

Identifiers

PMID41245593
PMCPMC12618808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.