Evidence map›Paper›PMID 41245581›Full record

ArticleGeoHealth2025

Impact of Air Pollution in Modifying the Relationship Between Climatic Variables and Hand, Foot and Mouth Disease: A Multi-City Time Series Study in Jiangsu Province, China.

Xin Liu, Ziying Chen, Huan Fan, Ruiyun Li, Zhe Lou, Hong Ji, Jianli Hu

Abstract read
In one paragraph

Article in GeoHealth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin LiuSchool of Public Health Nanjing Medical University Nanjing China.
Ziying ChenSchool of Public Health Nanjing Medical University Nanjing China.
Huan FanEarly Warning and Monitoring Institute Jiangsu Provincial Center for Disease Control and Prevention Nanjing China.
Ruiyun LiSchool of Public Health Nanjing Medical University Nanjing China.ORCID https://orcid.org/0000-0001-8927-9965
Zhe LouSchool of Public Health Nanjing Medical University Nanjing China.
Hong JiEarly Warning and Monitoring Institute Jiangsu Provincial Center for Disease Control and Prevention Nanjing China.
Jianli HuSchool of Public Health Nanjing Medical University Nanjing China.ORCID https://orcid.org/0009-0009-7749-4276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous research has primarily focused on the impact of climatic variables and air pollution on Hand, Foot, and Mouth Disease (HFMD). However, there remains limited understanding of how air pollution levels modify these relationships across different regions and populations. This study employed a two-stage, multi-city time-series analysis using data from 13 cities in Jiangsu Province (2015-2023) to explore these effects. A multistage analytical approach, including the distributed lag non-linear model, multivariate meta-regression, and attributable risk calculation, was used to quantify the association between climatic variables, air pollutants, and HFMD. Findings indicated that HFMD incidence is closely associated with meteorological conditions, with peak risk at 24.8°C for average temperature and 89.2% for average relative humidity. Low average wind speed and short sunshine hours (SH) also contributed to increased risk. Air pollutants, such as PM

Indexed as

air pollutionclimatic variablesDLNMHFMDmodification impactsubgroup analysis

Identifiers

PMID41245581
PMCPMC12616885

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.