Evidence map›Paper›PMID 41245566›Full record

ArticleACS materials Au2025

Three-Dimensional COF with "the" Topology as Enzyme Host: Comparative Insights into Activity, Stability, and Reusability in Surface versus Pore Immobilization Strategies.

Kohki Sasaki, Tsukasa Irie, Jin Sakai, Yu Zhao, Mika Nozaki, Tokuhisa Kawawaki, Saikat Das, Teng Ben, Yuichi Negishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS materials Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kohki SasakiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Tsukasa IrieInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Jin SakaiDepartment of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Yu ZhaoZhejiang Engineering Laboratory for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals, Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 321004 Jinhua, China.ORCID https://orcid.org/0000-0002-0281-0088
Mika NozakiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Tokuhisa KawawakiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.ORCID https://orcid.org/0000-0003-3282-8964
Saikat DasInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Teng BenZhejiang Engineering Laboratory for Green Syntheses and Applications of Fluorine-Containing Specialty Chemicals, Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 321004 Jinhua, China.ORCID https://orcid.org/0000-0002-0847-330X
Yuichi NegishiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.ORCID https://orcid.org/0000-0003-3965-1399

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) covalent organic frameworks (COFs) with high connectivity provide structurally rigid yet finely tunable scaffolds that enable precise enzyme immobilization by offering well-defined binding sites and framework stabilitykey to balancing substrate accessibility with enzyme protection, both critical for efficient biocatalysis. In this work, we investigate the effects of enzyme localizationsurface anchoring versus pore entrapmenton catalytic performance by employing two structurally distinct 3D COFs, TUS-39 and TUS-64, as host matrices. We herein report the designed synthesis of TUS-39, a new (8,3)-connected COF featuring

Indexed as

catalytic activitycovalent organic frameworklipase immobilizationrecyclabilitystability

Identifiers

PMID41245566
PMCPMC12616441

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.