Evidence map›Paper›PMID 41245563›Full record

ArticleACS materials Au2025

Dual-Functional Amine-Modified Aluminum-Doped MCM-41 Nanoparticles for Concurrent Zoledronic Acid Adsorption and Geranylgeraniol Delivery for Prevention of Medication-Related Osteonecrosis of the Jaw.

Pornchanok Pichaipanich, Weerachai Singhatanadgit, Boonlom Thavornyutikarn, Piyarat Sungkhaphan, Setthawut Kitpakornsanti, Soraya Pornsuwan, Wanida Janvikul

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In one paragraph

Article in ACS materials Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pornchanok PichaipanichNational Metal and Materials Technology Center, National Science and Technology Development Agency, Pathum-thani 12120, Thailand.
Weerachai SinghatanadgitFaculty of Dentistry and Research Unit in Mineralized Tissue Reconstruction, Thammasat University (Rangsit Campus), Pathum-thani 12121, Thailand.ORCID https://orcid.org/0000-0001-7594-1305
Boonlom ThavornyutikarnNational Metal and Materials Technology Center, National Science and Technology Development Agency, Pathum-thani 12120, Thailand.ORCID https://orcid.org/0000-0002-9814-0065
Piyarat SungkhaphanNational Metal and Materials Technology Center, National Science and Technology Development Agency, Pathum-thani 12120, Thailand.
Setthawut KitpakornsantiFaculty of Dentistry and Research Unit in Mineralized Tissue Reconstruction, Thammasat University (Rangsit Campus), Pathum-thani 12121, Thailand.
Soraya PornsuwanFaculty of Science, Mahidol University, Bangkok 10400, Thailand.ORCID https://orcid.org/0000-0003-4756-7891
Wanida JanvikulNational Metal and Materials Technology Center, National Science and Technology Development Agency, Pathum-thani 12120, Thailand.ORCID https://orcid.org/0000-0002-2560-0075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop a bifunctional nanomaterial that could simultaneously adsorb zoledronic acid (ZA) and release geranylgeraniol (GGOH) to reverse ZA-induced cytotoxicity. The synthesized aluminum-doped mesoporous silica nanomaterial (AM) was subsequently amine-functionalized by 3-aminopropyltriethoxysilane, generating both amine- and aluminum-containing nanomaterial (NAM), to enhance the ability of nanoparticles to adsorb GGOH. The comprehensive characterization results confirmed the successful aluminum-doping and amine-functionalization of the nanoparticles. The results acquired from both thermogravimetric analysis and high-performance liquid chromatography demonstrated that NAM, rather than AM, served as a good nanocarrier for GGOH loading and controlled-releasing. NAM exhibited up to 12.48% GGOH loading efficiency and GGOH sustained release for over 10 days with a release profile best fitted by the Higuchi model (

Indexed as

aluminum-doped mesoporous silica nanoparticleamine functionalizationdrug delivery and adsorptiongeranylgeraniolmedication-related osteonecrosis of the jawzoledronic acid

Identifiers

PMID41245563
PMCPMC12616448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.