Global, regional and national estimates of the burden of childhood asthma attributable to NO

Background: Asthma, a chronic lung condition characterised by inflammation and airway constriction, has been associated with nitrogen dioxide (NO Methods: We systematically reviewed epidemiological studies evaluating NO Findings: We identified a total of 27 cohort studies, spanning 12 countries, primarily in Europe and high-income North America, with some studies from Asia (China and Japan). A meta-regression log-linear risk curve of these studies produced a summary RR of 1.05 (95% UI 0.99-1.12) per 5 ppb NO Interpretation: NO Funding: The research described in this article was conducted in part under contract with the Health Effects Institute (HEI), an organization jointly funded by the United States Environmental Protection Agency (EPA) and certain motor vehicle and engine manufacturers, grant number 4977/20-11. The contents of this article do not necessarily reflect the views of HEI or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. Additional funding for this study was received by the Gates foundation, grant no. OPP1152504 for MB, KB, and SW. SA, DG, AM and GHK were supported by NASA grant no. 80NSSC21K0511 and SA and GHK NIH grant no. P20ES036775.