ArticleBiomaterials research2025
Tyr-Tyr-Glu Tripeptide for Regeneration of Articular Cartilage through Chondrogenic Differentiation of Mesenchymal Stem Cells.
Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Cell-based therapy accompanying articular cartilage regeneration is very promising as one of osteoarthritis (OA) treatments. Here, we report that Tyr-Tyr-Glu (YYE) is effective for articular cartilage regeneration through chondrogenic differentation of mesenchymal stem cells (MSCs). The expression of COL II, COMP, ACAN, and COL X at the mRNA and/or protein levels, together with Alcian Blue and Safranin O staining of 3-dimensionally cultured cell pellets, consistently demonstrated that YYE is an effective chondrogenic promoter of MSCs. Western blot, immunofluorescence, and molecular docking studies suggested that the chondrogenic up-regulation by YYE is mediated through YYE binding to FC-1, which induces translocation of core-binding factor β subunit (CBFβ) from the cytosol into the nucleus, followed by up-regulation of runt-related transcription factor 1 (RUNX1), which is a key factor for chondrogenic differentiation of MSCs. In particular, intra-articular injection of YYE to mouse OA models led to a significant improvements of OA as indicated by lowering OARSI grades and subchondral bone plate thickness, and thus proved its articular cartilage regeneration efficacy.
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Registered trials
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