ArticleBrain communications2025
Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study.
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Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Toward reliable thalamic segmentation: an evaluation of automated methods for structural MRI.Brain structure & function · 2026Article
- Corticothalamic circuit and executive dysfunction in Alzheimer's disease and related tauopathies.The Journal of physiology · 2026Article
- Diencephalic integrity explains aspects of hippocampal amnesia.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
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Authors and funding
42 authors.
Sonja SoskicDepartment of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.
Henry F J TregidgoDepartment of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.
Emily G ToddDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-1551-5691
Arabella BouziguesDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-0267-8590
David M CashDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-7833-616X
Lucy L RussellDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
David L ThomasNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, University College London, London WC1N 3BG, UK.
Ian B MaloneDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-7512-7856
Phoebe H FosterDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Eve Ferry-BolderDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam 2040 3000, The Netherlands.
Lize C JiskootDepartment of Neurology, Erasmus Medical Centre, Rotterdam 2040 3000, The Netherlands.ORCID https://orcid.org/0000-0002-1120-1858
Harro SeelaarDepartment of Neurology, Erasmus Medical Centre, Rotterdam 2040 3000, The Netherlands.ORCID https://orcid.org/0000-0003-1989-7527
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona 08036, Spain.ORCID https://orcid.org/0000-0001-7750-896X
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada.
Caroline GraffDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet, Solna 17177, Sweden.ORCID https://orcid.org/0000-0002-9949-2951
Daniela GalimbertiFondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan 20122, Italy.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium.ORCID https://orcid.org/0000-0001-6237-2502
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon 1649-004, Portugal.
Pietro TiraboschiFondazione IRCCS Istituto Neurologico Carlo Besta, Milano 20133, Italy.
Isabel SantanaNeurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra, Coimbra 3000-214, Portugal.
Alexander GerhardDivision of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Manchester M13 9GB, UK.ORCID https://orcid.org/0000-0002-8071-6062
Johannes LevinDepartment of Neurology, Ludwig-Maximilians Universität München, Munich 80539, Germany.ORCID https://orcid.org/0000-0001-5092-4306
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50139, Italy.
Markus OttoDepartment of Neurology, University of Ulm, Ulm 89081, Germany.
Maxime BertouxLille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille, Lille 59000, France.ORCID https://orcid.org/0000-0002-5283-503X
Thibaud LebouvierLille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille, Lille 59000, France.
Simon DucharmeDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Québec H3H 2R9, Canada.ORCID https://orcid.org/0000-0002-7309-1113
Christopher R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford OX1 4BH, UK.ORCID https://orcid.org/0000-0002-7502-9284
Isabelle Le BerDépartement de Neurologie, AP-HP-Hôpital Pitié-Salpêtrière, Centre de référence des démences rares ou précoces, IM2A, Paris 5783, France.
Elizabeth C FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON N6A 5A5, Canada.ORCID https://orcid.org/0000-0003-4461-7427
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M4N 3M5, Canada.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto M4N 3M5, Canada.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 1TN, UK.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen 72074, Germany.ORCID https://orcid.org/0000-0002-2280-7273
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian 20014, Spain.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy.ORCID https://orcid.org/0000-0001-9340-9814
Daniel C AlexanderDepartment of Computer Science, UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.
Juan Eugenio IglesiasDepartment of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.
Jonathan D RohrerDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Martina BocchettaDepartment of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-1814-5024
GENetic Frontotemporal dementia Initiative (GENFI)
Funding
Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9MAcquisition-independent machine learning for morphometric analysis of underrepresented aging populations with clinical and low-field brain MRIRF1AG080371 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Juan Eugenio Iglesias Gonzalez · 2023 to 2026
$4.0MDiagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7MOpen-source software for multi-scale mapping of the human brainRF1MH123195 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, IGLESIAS GONZALEZ, JUAN EUGENIO · 2020 to 2020
$2.0MMeasuring Brain Health Using Low-Field Portable MRIR21NS138995 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2024 to 2024
$477kNIA NIH HHS R01 AG070988NIA NIH HHS RF1 AG080371NIMH NIH HHS RF1 MH123195NIMH NIH HHS UM1 MH130981NINDS NIH HHS R21 NS138995Wellcome Trust
Abstract
Thalamic subregions are commonly, but variably, affected by different forms of frontotemporal dementia. We aimed to better characterize thalamic subregional involvement in genetic frontotemporal dementia with a recently published thalamus segmentation tool that utilizes structural and diffusion MRI, offering additional assessment of mean diffusivity and a more fine-grained analysis of the pulvinar specifically compared to previous studies. Using this tool, we performed thalamus segmentations in MRI scans from
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diffusion tensor imagingfrontotemporal dementiageneticsMRIthalamus
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