Evidence map›Paper›PMID 41245259›Full record

ArticleFrontiers in cellular and infection microbiology2025

Integrated periodontal pathogens and circulating miRNAs: a novel non-invasive panel of biomarkers for pancreatic cancer.

Zeinab Hesami, Valerio Pazienza, Meysam Olfatifar, Amir Sadeghi, Samira Mohammadi-Yeganeh, Nadia Trivieri, Hesameddin Eghlimi, Mojdeh Hakemi-Vala, Elena Binda, Hamidreza Houri

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeinab HesamiDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Valerio PazienzaGastroenterology Unit IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo/FG, Italy.
Meysam OlfatifarGastroenterology and Hepatology Diseases Research Center, Qom University of Medical Sciences, Qom, Iran.
Amir SadeghiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Samira Mohammadi-YeganehDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nadia TrivieriCancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo/FG, Italy.
Hesameddin EghlimiDepartment of General Surgery, Ayatollah Taleghani Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Mojdeh Hakemi-ValaDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elena Binda *Cancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo/FG, Italy.
Hamidreza Houri *Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The associations between oral bacterial pathogens and the risk of pancreatic cancer (PC) have been reported in several epidemiological studies. In this study, we evaluated the diagnostic potential of periodontal pathogens Methods: A total of 41 PC patients and 40 age- and sex-matched controls were recruited for the study. The salivary bacterial load of Results: Elevated load of the periodontal pathogens Discussion: This study offers compelling new evidence supporting the idea that the combined analysis of salivary microbiota and circulating miRNAs serves as an informative avenue for the discovery of non-invasive biomarkers for PC, potentially applicable to early detection and clinical screening.

Indexed as

Biomarkers, TumorCirculating MicroRNAMicroRNAsPancreatic NeoplasmsAgedAggregatibacter actinomycetemcomitansBacterial LoadBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPorphyromonas gingivalisROC CurveSalivaBiomarkersBiomarkers, TumorCirculating MicroRNAMicroRNAsMIRN155 microRNA, humancancer diagnosiscirculating miRNAsnon-invasive biomarkerspancreatic cancerperiodontal pathogens

Identifiers

PMID41245259
PMCPMC12615387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.