ArticleFrontiers in cellular and infection microbiology2025
Microbial profile and putative microbial origin of anorectal abscess based on 16S rDNA sequencing.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anorectal abscess is a common bacterial infectious disease; however, its pathogenesis remains unclear. Although there is emerging evidence linking gut microbiota to anorectal abscesses, knowledge of the microbial origin of this disease remains limited. This study analyzed the microbial profile of anorectal abscesses using 16S rDNA sequencing and investigated their microbial origin with the aim of providing a reference for subsequent studies. Methods: We recruited 60 patients with anorectal abscesses (AA group) and 26 healthy individuals (HC group) and used 16S rDNA V3-V4 hypervariable region gene sequencing to analyze the microbiota in feces, pus, and perianal buttock skin samples. The gut microbiota and perianal buttock skin flora were compared between the two groups, pus flora was analyzed in relation to the gut and perianal buttock skin microbiota, and microbial traceability analysis of pus was performed. Results: There were significant differences in the gut microbiota between the AA and HC groups. Conclusion: Our study provides a microbiomic panorama and putative microbial origin of anorectal abscesses, potentially offering new insights into their etiology, prevention, and treatment.
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