ArticleFrontiers in cellular and infection microbiology2025
The innovative diagnostic model facilitates the differentiation between non - tuberculous mycobacterial lung disease and pulmonary tuberculosis.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Objectives: To construct a differential diagnostic model for Non-Tuberculous Mycobacterial Lung Disease (NTM-LD) and Pulmonary Tuberculosis Lung Disease (PTB-LD). Methods: Retrospective analysis of 300 NTM-LD and 300 PTB-LD patients (pathogen-confirmed) was performed. Patients were randomly split into training (2/3) and validation (1/3) sets. CT imaging, clinical data, and symptoms were analyzed. Logistic regression identified significant discriminative features, followed by random forest modeling to develop a diagnostic tool with web-based calculator. Model performance was validated using the independent validation set. Results: Univariate and multivariate analyses identified key discriminative factors ( Conclusions: The model constructed based on patients' CT imaging, basic clinical data, and symptomatic signs demonstrates commendable performance in the differential diagnosis of NTM-LD and PTB-LD, offering a convenient and practical auxiliary tool for clinical practice.
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