Evidence map›Paper›PMID 41245247›Full record

ArticleFrontiers in chemistry2025

Method for simultaneous determination of three cooling agents in aerosols by GC-MS.

Tinghao Chen, Chenfeng Hua, Chengjie Ma, Bin Peng, Pingping Shang, Ge Zhao, Quanping Yan, Fuwei Xie

Abstract read
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Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tinghao ChenKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Chenfeng HuaKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Chengjie MaKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Bin PengKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Pingping ShangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Ge ZhaoKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Quanping YanKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.
Fuwei XieKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of China National Tobacco Corporation (CNTC), Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A cooling sensation is primarily elicited by cooling agents through activation of cold-sensitive receptors such as TRPM8 and TRPA1. Coolants are widely used as functional additives in various industries including food, personal care, pharmaceuticals, and tobacco. In this study, a gas chromatography-mass spectrometry (GC-MS) method was developed to quantify three representative cooling agents-menthol, WS-3(N-ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide), and WS-23 (2-Isopropyl-N,2,3-trimethylbutyramide)-in aerosol samples. The test aerosols were generated from laboratory-formulated e-liquids under optimized conditions. Aerosols were obtained from an electronic vaping device manufactured by RELX (China). The results demonstrated that: (1) the analytical method exhibited good linearity (

Indexed as

aerosolcooling agentgas chromatography-mass spectrometrymentholmethod validation

Identifiers

PMID41245247
PMCPMC12616255

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