ArticleFrontiers in human neuroscience2025
Deep brain stimulation of the anterior nucleus of the thalamus for seizures after new-onset refractory status epilepticus: a case report.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A comprehensive review of deep brain stimulation for drug-resistant epilepsy.Frontiers in neurologyReview
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7 authors.
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Abstract
Objectives: Most patients with new-onset refractory status epilepticus (NORSE) subsequently develop drug-resistant epilepsy (DRE) with multiple seizure foci and are not the typical candidates for resective surgery. We report the first case of DRE developing after cryptogenic-NORSE (C-NORSE) that was successfully treated using deep brain stimulation targeting the anterior nucleus of the thalamus (ANT-DBS). Methods: A 52-year-old man developed C-NORSE at the age of 45 years and presented with sequelae of DRE and cognitive dysfunction despite anti-seizure medications and immunotherapy administration. Seizure semiology comprised palpitations, chills, and nausea, followed by impairment of awareness with oral automatism multiple times a day. Video-electroencephalogram monitoring (vEEG) showed bilateral independent electrographic seizures (ESz) in the fronto-temporal areas. He underwent ANT-DBS. Preoperative and postoperative vEEG recordings for 3 days were compared. Results: Preoperative vEEG showed 11 clinical seizures correlated with ESz. The duration of ESz ranged from 55 to 213 s (median, 81 s). Three months after ANT-DBS stimulation, vEEG showed four subclinical ESz episodes lasting from 22 to 31 s (median, 25.5 s) (Mann-Whitney Conclusion: ANT-DBS is an effective treatment option for DRE after NORSE, particularly when the epileptogenic network is located in the temporal lobe. A detailed evaluation using vEEG is useful for identifying the epileptogenic foci and assessing therapeutic outcome. Immunomodulatory mechanisms via cytokines could play roles in the pathogenesis of development of DRE after NORSE and seizure suppression effect of ANT-DBS.
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