Evidence map›Paper›PMID 41245179›Full record

ArticleFood science & nutrition2025

Genetically Predicted Sarcopenia Traits and the Risk of Barrett's Esophagus.

Jianfeng Zhou, Dexiu E, Yuwen Tan, Yixin Liu, Pinhao Fang, Zhi Ye, Yushang Yang

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianfeng ZhouDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu Sichuan China.
Dexiu EDepartment of Thoracic Surgery Qinghai Provincial People's Hospital Xining Qinghai China.
Yuwen TanGuangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital Sun Yat-Sen University Zhuhai Guangdong China.
Yixin LiuDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu Sichuan China.
Pinhao FangDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu Sichuan China.
Zhi YeDepartment of Thoracic Surgery Qinghai Provincial People's Hospital Xining Qinghai China.
Yushang YangDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu Sichuan China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of cohort research suggests a link between sarcopenia and Barrett's esophagus (BE); however, a definitive causal connection has yet to be established. Consequently, this study aims to evaluate the potential causal association between sarcopenia and BE. We obtained data on single-nucleotide polymorphisms (SNPs) linked to appendicular lean mass, hand grip strength, and walking speed, as well as outcome data related to Barrett's esophagus, from publicly available genome-wide association studies (GWAS). Utilizing these datasets, we conducted a multivariable Mendelian randomization (MR) analysis to explore potential causal associations. Univariable MR revealed significant inverse associations between sarcopenia-related traits and BE risk. Specifically, higher appendicular lean mass, stronger grip strength, and faster walking pace were each associated with reduced BE risk (all

Indexed as

appendicular lean massBarrett's esophaguscausal associationgrip strengthMendelian randomizationwalking speed

Identifiers

PMID41245179
PMCPMC12614087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.