Penile squamous cell carcinoma in neurofibromatosis type 1 (NF1): RAS-pathway mechanisms and management - A case report.

Babak Javanmard, Sina Samenezhad, Dorna Rafighi, Lena Yaghoubpour, Nasim Dehghan

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Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Babak JavanmardUrology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sina SamenezhadUrology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Dorna RafighiDepartment of Microbiology, Faculty of Basic Sciences, Research Sciences Branch, Islamic Azad University, Tehran, Iran.

Lena YaghoubpourUrology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Nasim DehghanDepartment of Pathology, Shohada-e-tajrish Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) predisposes to neural and occasionally epithelial malignancies. We report a 65-year-old man with NF1 who presented with urethral obstruction, meatal discharge, and glans swelling. Imaging identified a 22 × 25 mm hypervascular penile lesion invading the corpus spongiosum and anterior urethra. Biopsy confirmed well-differentiated squamous cell carcinoma. Staging showed no distant disease; inguinal FNA was negative. He underwent radical penectomy with perineal urethrostomy; margins were clear, and recovery was uneventful. This rare occurrence highlights RAS-pathway plausibility, supports prompt biopsy of changing genital lesions in NF1, and recommends HPV testing, molecular profiling, and multidisciplinary follow-up.

Identifiers

PMID41245174

DOI10.1016/j.eucr.2025.103257

PMCPMC12617642

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