ArticleJournal of the Endocrine Society2025
Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight.
Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight.Journal of the Endocrine Society · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Sources of androgen overproduction in peripubertal girls with overweight/obesity (excess weight [EW]) remain unclear. Objective: To assess 17-hydroxyprogesterone (17-OHP) responses to recombinant human chorionic gonadotropin (r-hCG) in peripubertal girls with and without EW. We hypothesized that 17-OHP responses are exaggerated in late pubertal girls with EW compared to those without EW, but similar in early pubertal girls with and without EW. Methods: This cross-sectional study conducted at an academic clinical research unit included 45 girls ages 7 to 18 years: 6 early pubertal (Tanner 1-3) with EW and 8 without; 20 late pubertal (Tanner 4-5) with EW and 11 without. Research volunteers took oral dexamethasone (1 mg) at 22:00 hours on study days 1 and 2. On study day 2, volunteers had blood withdrawal at 08:00 hours and r-hCG administration (25 mcg intravenously) at 09:00 hours, with repeat blood withdrawal at 09:00 hours on study day 3; the 17-OHP increment was analyzed. Results: 17-OHP responsiveness was 2.31-fold (95% CI, 1.13-4.73) greater in early pubertal girls with EW compared to those without (Bonferroni-corrected Conclusion: Ovarian responsiveness to r-hCG stimulation during early puberty may be exaggerated in the setting of EW, but excess-weight status per se may not promote long-term ovarian hyperresponsiveness to r-hCG.
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Registered trials
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