Evidence map›Paper›PMID 41245141›Full record

ArticleASM case reports2025

Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis.

Shmuel Shoham, Sabin Thapaliya, Robin Avery, John Baddley, Veronica Dioverti, Christine Durand, Ahmet Gurakar, Andrew Karaba, Olivia Kates, Nicholas Maragakis and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ASM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shmuel ShohamDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-7276-7786
Sabin ThapaliyaDepartment of Internal Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Robin AveryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
John BaddleyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Veronica DiovertiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christine DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ahmet GurakarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andrew KarabaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Olivia KatesDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nicholas MaragakisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nitipong PermpalungDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-0749-7342
William WerbelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-9402-9167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Meningitis due to Case Summary: In this report, we present a case of cryptococcal meningitis in a liver transplant recipient whose disease manifestations were due to (i) fungal invasion, (ii) elevated intracranial pressure, and (iii) an over-exuberant immune response that blossomed soon after reduction of immunosuppression and clearance of cerebrospinal fluid culture. Conclusion: This patient's course exemplifies the multidimensional nature of neurological injury in cryptococcal meningitis and the diverse treatment strategies required to address the infection and complications. IMPORTANCE: An understanding of the pathophysiological processes that cause neurological damage in cryptococcal meningitis is critical for optimal management of patients with this infection. This case highlights three such processes so that they can be quickly diagnosed and treated before irreversible damage occurs.

Indexed as

central nervous systemCryptococcus neoformansfungalimmune mechanismsintracranial pressuremeningitis

Identifiers

PMID41245141
PMCPMC12530241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.