ArticleFrontiers in aging neuroscience2025
Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cognitive frailty, defined by the coexistence of mild cognitive impairment and physical frailty, imposes greater risk of negative health consequences than either condition alone. Cognitive intraindividual variability (IIV), which reflects the extent of fluctuation in cognitive performance, is an early indicator of impaired cognition and mobility. To extend current understanding of the underlying neural mechanisms of increased IIV due to cognitive frailty, this study investigated the association between brain networks, IIV, and mobility. Methods: A total of 38 community-dwelling cognitively frail/non-cognitively frail older adults (CF and non-CF; Results: Compared to non-CF group, CF group exhibited greater IIV-dispersion ( Discussion: Greater IIV-dispersion due to cognitive frailty may be underpinned by large-scale altered functional connectivity across networks. However, localized reconfiguration of DMN-FEN connectivity may uniquely represent adaptive compensatory processes by which mobility is protected against the detrimental impact of greater IIV-dispersion secondary to cognitive frailty.
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