ArticleTherapeutic advances in drug safety2025
Risk of seizure in patients with prostate cancer treated with enzalutamide in China: a noninterventional study.
Article in Therapeutic advances in drug safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Enzalutamide, approved in China for the treatment of prostate cancer (PC), has been studied for risk of seizure, but there is limited real-world evidence on this risk in China. Cases of posterior reversible encephalopathy syndrome (PRES) among enzalutamide-treated patients have been reported. Objectives: To evaluate the risk of seizure and PRES in patients with PC treated with enzalutamide in China. Design: Observational cohort study. Methods: Data were extracted from electronic medical records of patients with PC aged ⩾18 years treated at three clinical sites in China who started enzalutamide between March 1, 2020 and May 31, 2022. The primary objective was to estimate the proportion (%) of enzalutamide- or alternative antiandrogen-treated patients who experienced seizure. The index date was the date of the start of treatment. The follow-up period started from the index date and included both on- and off-treatment periods. Results: Demographic and clinical characteristics were generally similar between the enzalutamide ( Conclusion: Among patients with PC in China, the risk of seizure was low in both the enzalutamide and alternative antiandrogen groups, despite the presence of risk factors for seizure in over one-third of patients.
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