ArticleACS bio & med chem Au2025
High-Throughput Microfluidic Technologies for Rapidly Screening Pollutant-Induced Cell Health Effects.
Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gero-Immunology: The critical role of aging when defining immune phenotypes.Current opinion in biomedical engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Air pollution exposure is linked to diseases spanning multiple physiological systems. However, environmental stress is overwhelmingly associated with several lung diseases. Since the chemical composition of air pollutants varies widely across geographical locations, research on how specific components in pollutant mixtures contribute to cellular dysfunction is needed. In this work, we utilized microscopy-based morphological profiling as a tool to assess the cellular susceptibility to pollutants. Through our analysis, we established morphological profiles of formaldehyde-exposed cells that showed dose-dependent shifts in cell shape profiles correlating with overall cell health. As a real-world proof-of-concept validation, we evaluated the differences in particulate matter (PM) composition across multiple geographical areas, including both urban and suburban communities in Austin, Texas, USA. Data from this real-world study was used to inform a multicombinatorial study involving metals, selenium (Se) and manganese (Mn), which were differentially abundant across PM collection sites. As proof of concept to demonstrate the potential of establishing low-cost, high-throughput combinatorial screening of the biological effects of these metals, we incorporated microfluidic technology to simultaneously generate variable two-component metal mixtures in a multiwell plate format that enabled microscopy-based morphological screening as a proxy for toxicity. Combinatorial analysis of Se and Mn showed dynamic cell responses across a range of concentrations. Interestingly, exposure mixtures containing both Se and Mn yielded healthier cellular phenotypes relative to Se exposure as a single component. These results demonstrate the development of a high-throughput pipeline to detect dynamic biological responses to common air pollutants. Leveraging multiple technologies, we demonstrate the feasibility of a cost-effective approach that can serve as a starting point to inform focused screenings and studies of air pollutant mixtures that affect health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.