Evidence map›Paper›PMID 41245050›Full record

ArticleJPGN reports2025

Delayed presentation of a retained colonic segment in a child with intestinal failure on teduglutide.

Rachel C Bordelon, Sarah J Varalla, Varaha S Tammisetti, Mohamed M Shahin, Amanda Tchakarov, Essam Imseis, Allison L Speer

Abstract read
In one paragraph

Article in JPGN reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachel C BordelonDepartment of Pediatric Surgery McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.ORCID https://orcid.org/0009-0006-8167-7962
Sarah J VarallaDepartment of Pediatric Surgery McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.
Varaha S TammisettiDepartment of Diagnostic and Interventional Imaging McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.
Mohamed M ShahinDepartment of Diagnostic and Interventional Imaging McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.
Amanda TchakarovDepartment of Pathology McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.
Essam ImseisShort Bowel Syndrome Therapy and Rehabilitation (STAR) Team, McGovern Medical School, The University of Texas Health Science Center at Houston and Children's Memorial Hermann Hospital Texas Medical Center Houston Texas USA.
Allison L SpeerDepartment of Pediatric Surgery McGovern Medical School at the University of Texas Health Science Center at Houston Houston Texas USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teduglutide is a glucagon-like peptide 2 (GLP-2) analogue that was approved by the United States Food and Drug Administration for the treatment of pediatric (>1 year) intestinal failure due to short bowel syndrome in 2019. GLP-2 analogues promote rapid intestinal adaptation, increasing the absorptive capacity of residual intestine after surgical resection to aid the achievement of enteral autonomy or reduce parenteral nutrition requirements. Despite relatively few reported side effects, there is a theoretical risk of proliferative complications. Here we present an intriguing case of a pediatric patient found to have a decade-long retained, discontinuous segment of colon from a surgical procedure performed in infancy, which became clinically significant after a period of treatment with teduglutide.

Indexed as

enteral autonomyintestinal adaptationlaparotomynutritionshort bowel syndrome

Identifiers

PMID41245050
PMCPMC12611565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.