Evidence map›Paper›PMID 41245039›Full record

ArticleJPGN reports2025

Pyridostigmine as treatment for chronic gastrointestinal dysmotility in a child with Mowat-Wilson syndrome: A case report and literature review.

Grace J Lin, Shreya B Kishore, Sally Samaan, Lisa S Hackett, Kevan Jacobson, Gabriella Horvath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPGN reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grace J LinDepartment of Pediatrics, BC Children's Hospital University of British Columbia Vancouver British Columbia Canada.ORCID https://orcid.org/0009-0007-5997-3009
Shreya B KishoreDepartment of Pediatrics BC Children's Hospital, British Columbia & Griffith University School of Medicine Vancouver Brisbane Australia.
Sally SamaanDepartment of Pediatrics BC Children's Hospital, British Columbia & Ain Shams University Vancouver Cairo Egypt.
Lisa S HackettDepartment of Pediatrics, BC Children's Hospital University of British Columbia Vancouver British Columbia Canada.
Kevan JacobsonDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, BC Children's Hospital University of British Columbia Vancouver British Columbia Canada.
Gabriella HorvathDepartment of Pediatrics, Division of Biochemical Genetics, BC Children's Hospital University of British Columbia Vancouver British Columbia Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal dysmotility is commonly reported among patients with Mowat-Wilson syndrome (MWS) and poses a significant symptomatic burden. Unfortunately, there remains a knowledge gap regarding effective treatment strategies. A 2-year-old male with MWS presented with chronic paradoxical abdominal pain, constipation, and progressively restricted oral intake. He was diagnosed with intestinal pseudo-obstruction, due to recurrent transient small bowel intussusception identified on ultrasound. Pyridostigmine, an acetylcholinesterase inhibitor, was successfully used to promote gastrointestinal motility, improving the child's pain symptoms and allowing return to his baseline activities. This case adds to emerging evidence of low-dose pyridostigmine as a viable treatment to consider for children with symptoms related to impaired gastrointestinal motility, by demonstrating its successful use in a child with MWS for the first time.

Indexed as

gastrointestinal motilitygeneticspediatric gastroenterologypediatric intestinal pseudo‐obstruction

Identifiers

PMID41245039
PMCPMC12611612

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.