Evidence map›Paper›PMID 41245032›Full record

ArticleJPGN reports2025

Drug-induced liver injury associated with selective androgen receptor modulators in an adolescent patient.

David J Katibian, Laura E Bauman, Katayoon Shayan, D Brent Polk

Abstract read
In one paragraph

Article in JPGN reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David J KatibianDepartment of Pediatrics University of California, La Jolla San Diego California USA.ORCID https://orcid.org/0000-0003-4027-093X
Laura E BaumanDepartment of Pediatrics University of California, La Jolla San Diego California USA.
Katayoon ShayanDepartment of Pathology University of California, La Jolla San Diego California USA.
D Brent PolkDepartment of Pediatrics University of California, La Jolla San Diego California USA.

Funding

CYTOKINE REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONR01DK056008 · NIDDK · VANDERBILT UNIVERSITY · PI POLK, D BRENT · 1999 to 2020
$6.8M
Stem Cell Dynamics in Colonic Epithelial RepairR01DK108648 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Cambrian Yangshao Liu, D Brent Polk · 2016 to 2026
$2.7M
NIDDK NIH HHS R01 DK056008NIDDK NIH HHS R01 DK108648
6 · The paper itself

Abstract

Selective androgenic receptor modulators (SARMs) have similar properties to anabolic steroids but bind to androgen receptors in a tissue-specific manner. Studies have investigated the benefits of SARMs in promoting bone and muscle growth while limiting the adverse effects of androgenic stimulation of other organs. However, an increase in the reported cases of hepatotoxicity in adults secondary to SARMs found in bodybuilding supplements has raised concerns about their safety. We report the first known adolescent case of SARMs-associated liver injury with a primarily hepatocellular pattern of injury. Previous reports in adults had shown a primarily cholestatic pattern of injury. Our case highlights, the variations in the phenotypic and histologic patterns of injury based on the amount and type of SARMs. The purpose of this case report is to shed light on the potential spectrum of liver injury related to SARMs use and continue to raise awareness of the associated health risks.

Indexed as

hepatotoxicitySARMssupplements

Identifiers

PMID41245032
PMCPMC12611585

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.