ArticleFrontiers in oncology2025
The impact of maximized resection and standardized systemic therapy on overall survival in adult patients with thalamic gliomas.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Laser insterstitial thermal therapy followed by craniotomy for tumor resection for pediatric diffuse midline glioma: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to explore the impact of maximized resection and standardized systemic surgery + chemoradiotherapy(SRC) on the survival prognosis of adult thalamic glioma, and to construct a clinical prognosis model of adult thalamic glioma. Methods: A retrospective analysis was conducted on adult cases of thalamic glioma who underwent craniotomy in the Department of Neurosurgery of West China Hospital of Sichuan University from 01/03/2009 to 01/03/2024. Firstly, Kaplan-Meier survival analysis and subgroup analysis were conducted. Secondly, COX regression and LASSO-COX regression were performed on 12 variables respectively to screen the variables and construct a prognostic model. Then, the efficacy of different models was compared to select the optimal model to construct a prognostic nomogram for the overall survival of thalamic glioma. Results: Total of 192 adult patients with thalamic glioma were included in this study, of whom 84 underwent surgery only, 41 underwent surgery + radiotherapy/chemotherapy(SR/SC), and 67 completed SRC. Among them, 79 patients(41.1%) completed gross-total tumor resection during the operation, and 113 patients(58.9%) completed non-gross-total tumor resection. The efficacy of the three models was compared. The optimal LASSO-COX model included five variables that affected the overall survival(OS) of thalamic glioma (EOR, diagnosis, preoperative hydrocephalus, postoperative KPS, treatment). Then, these five variables were utilized to develop prognostic nomograms for predicting the 6-, 12-, 24-, 36-, and 60-month OS. The nomogram shows good predictive ability and clinical practicability. Finally, the risk stratification system based on the prognostic nomogram effectively divided patients into the high-risk group and the low-risk group. Conclusions: Maximized tumor resection within safe parameters with standardized systemic SRC significantly prolong the OS of patients with thalamic glioma. The survival prognosis nomogram based on LASSO-COX regression in this study can be used as a practical tool for predicting the survival probability of patients with thalamic glioma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.