Evidence map›Paper›PMID 41244838›Full record

ArticleFrontiers in pharmacology2025

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing.

Jian Wu, Yifang Sun, Shuyue Wang, Qian Zhang, Ying Lin, Caipeng Liu, Maomao Ai, Feng Yu, Lei Cao

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In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jian Wu *Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Yifang Sun *Department of Ophthalmology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Shuyue Wang *Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Qian ZhangDepartment of Otorhinolaryngology, The Forth People's Hospital of Guiyang, Guiyang, Guizhou, China.
Ying LinDepartment of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Caipeng LiuDepartment of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Maomao AiDepartment of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Feng Yu *Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
Lei Cao *Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP), an inflammatory condition of unclear etiology, may involve immune dysregulation and metabolic alterations. Methods: Utilizing Mendelian randomization, we investigated causal links between CRSwNP and profiles of 731 immune cell types and 1,400 metabolites. Single-cell RNA sequencing (scRNA-seq) was employed for cell type identification and transcription factor analysis. Metabolic profiling characterized cellular subpopulations, while Gene Set Enrichment Analysis (GSEA) and machine learning pinpointed key genes functionally linked to immune and inflammatory pathways (categorized via WGCNA and Metascape). Results: We identified expression of HLA-DR on CD33- HLA-DR + B cells and the lipid metabolite 1-stearoyl-2-arachidonoyl as risk factors for CRSwNP. scRNA-seq further revealed these specific B cell subpopulations exhibit metabolic levels linked to immune responses. Bulk RNA analysis confirmed upregulation of genes CD27 and DERL3, while machine learning identified a signature of ten key genes showing positive correlation with B cell regulatory functions. Conclusion: This integrated study advances understanding of immune-metabolic crosstalk in CRSwNP pathogenesis, highlighting the role of metabolite-influenced B cell subsets in shaping the immune microenvironment, thereby suggesting novel therapeutic targets.

Indexed as

B-cellCRSwNPimmunityMendelian randomizationmetabolismsingle-cell RNA sequencing

Identifiers

PMID41244838
PMCPMC12611945

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