Evidence map›Paper›PMID 41244811›Full record

ArticleJournal of pediatrics. Clinical practice2025

Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN).

Marina S Oren, Kikelomo Babata, June Hu, Venkatakrishna Kakkilaya, Patti J Burchfield, Michelle Hagans, L Steven Brown, Satyan Lakshminrusimha, Vishal Kapadia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatrics. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marina S OrenDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Kikelomo BabataDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
June HuDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Venkatakrishna KakkilayaDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Patti J BurchfieldDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Michelle HagansNICU Data Analyst, Texas Health Presbyterian Hospital of Dallas, Dallas, TX.
L Steven BrownDepartment of Health Systems Research, Parkland Health & Hospital System, Dallas, TX.
Satyan LakshminrusimhaDivision of Neonatology, Department of Pediatrics, UC Davis Children's Hospital, Sacramento, CA.
Vishal KapadiaDivision of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether oxygenation levels and exposure to hyperoxemia in the first 12 postnatal hours are associated with death in neonates treated with inhaled nitric oxide for persistent pulmonary hypertension of newborn (PPHN). Study design: This was a retrospective study of neonates ≥35 weeks with PPHN treated with inhaled nitric oxide. The cohort was divided into 4 groups on the basis of maximum Pao Results: In total, 118 neonates were included. Hypoxemia, normoxemia, and mild-to-moderate and severe hyperoxemia were present in 14%, 36%, 32%, and 17% of infants, respectively. Mortality followed a U-shaped relationship, with significantly greater rates in hypoxemia (23%) and the severe hyperoxemia (30%) groups and no deaths in the normoxemia group ( Conclusions: Early hypoxemia and severe hyperoxemia were associated with mortality in infants with PPHN. These findings underscore the importance of cautious oxygen titration. Prospective studies are needed to establish optimal oxygen management strategies in this population.

Indexed as

hyperoxiamortalityoutcomesoxygenoxygen saturationpersistent pulmonary hypertension of newbornSpo2

Identifiers

PMID41244811
PMCPMC12617620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.