ArticlePain research & management2025
Association Between Chronic Pain and Jumping-to-Conclusions Behaviour.
Article in Pain research & management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: A tendency to jumping to conclusions (JTCs) was described in schizophrenia, in functional movement disorders and recently in a mixed group of chronic pain patients and has been discussed to indicate prefrontal dysfunction. This study investigated the tendency to premature decisions (JTC) in patients with complex regional pain syndrome (CRPS), a severe disorder affecting predominantly the distal limb, compared to healthy individuals and those with chronic limb pain from other causes, such as nerve injury or musculoskeletal abnormalities (non-CRPS). Methods: In the classic 'beads task', visual stimuli were used to assess evidence-based decision-making ability, followed by a variation with somatosensory stimuli. Thirty patients with CRPS were compared to 23 non-CRPS patients and 30 healthy individuals. Results were related to clinical data such as pain intensity, disease duration, CRPS phenotype based on predominant symptoms (central, peripheral and mixed) and standardized questionnaires evaluating depressive and anxiety symptoms. The main outcome was the number of draws to decision (DTD), i.e., how many beads participants requested before making a final judgement. Group differences were analysed using AN(C)OVA or Kruskal-Wallis tests with Bonferroni-corrected post hoc comparisons, unpaired Results: Both CRPS and non-CRPS patients showed a significantly stronger JTC tendency, deciding at a lower DTD (2.63 ± 1.19 and 2.65 ± 1.27, respectively) than healthy controls (5.13 ± 1.92, both Conclusion: Dysfunctional processes leading to JTC seem to play a role in chronic pain patients and interact with depressive and anxiety symptoms. These interactions may impact treatment outcomes and warrant further investigation.
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