ArticleRSC advances2025
Enhanced sensitivity of lateral flow assay for NGAL detection using cysteamine-modified gold nanoparticles.
Paweena Tunakhun, Sawinee Ngernpimai, Patcharaporn Tippayawat, Kiattawee Choowongkomon, Sirirat Anutrakulchai, Nicha Charoensri, Ratree Tavichakorntrakool, Sakda Daduang, Oranee Srichaiyapol, Pornsuda Maraming and 3 more
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In one paragraphArticle in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Paweena TunakhunCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.ORCID https://orcid.org/0009-0003-0709-1865 Sawinee NgernpimaiDepartment of Biochemistry, Faculty of Science, Khon Kaen University Khon Kaen 40002 Thailand.
Patcharaporn TippayawatCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.
Kiattawee ChoowongkomonDepartment of Biochemistry, Faculty of Science, Kasetsart University Bangkok 10900 Thailand.
Sirirat AnutrakulchaiDepartment of Medicine, Faculty of Medicine, Khon Kaen University Khon Kaen 40002 Thailand.
Nicha CharoensriCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.ORCID https://orcid.org/0000-0002-0679-9883 Ratree TavichakorntrakoolCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.
Sakda DaduangDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University Khon Kaen 40002 Thailand.
Oranee SrichaiyapolCenter for Innovation and Standard for Medical Technology and Physical Therapy (CISMaP), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand.
Pornsuda MaramingCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.
Jeerati PrompipakCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.
Patcharee BoonsiriDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University Khon Kaen 40002 Thailand.
Jureerut DaduangCentre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University Khon Kaen 40002 Thailand Jurpoo@kku.ac.th.ORCID https://orcid.org/0000-0003-0977-4144 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a crucial biomarker for various clinical conditions, including acute kidney injury. However, enhancing the sensitivity of the lateral flow strip (LFS) for NGAL detection remains a challenge. LFS has revolutionized point-of-care diagnostics, offering rapid and cost-effective detection of biomarkers. This study explores the potential of cysteamine gold nanoparticles (AuNPs) as a novel conjugate for NGAL detection in LFS, comparing their sensitivity enhancement against traditional citrate-coated AuNPs (Cit-AuNPs). Through comprehensive experimentation and analysis, we demonstrate the superior performance of cysteamine-coated AuNPs (Cys-AuNPs) LFS in detecting NGAL, paving the way for more sensitive point-of-care diagnostics in relevant clinical settings.
Identifiers
PMID41244718
PMCPMC12613825
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