ArticleFrontiers in microbiology2025
Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A novel enterotype enriched with respiratory super-dominant pathobionts is associated with immunosuppression in pulmonary tuberculosis patients.Journal of translational medicine · 2026Article
- Association Between Gut Microbiota and HIV Infection Risk: Insights from Mendelian Randomization and 16S rRNA Amplicon Sequencing.Microorganisms · 2026Article
- Shared and condition-associated gut microbiota alterations in older adults with depression and constipation: evidence from the American Gut Project.Frontiers in microbiology · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
Chronic hepatitis B (CHB) remains a significant global health challenge, with research indicating the gut microbiota's influence on disease progression, although investigations have primarily been limited to the genus level. This study conducted species-level research using the Human Gut Microbiome Analysis Database (HGMAD) to examine differences in gut microbiota between CHB patients and healthy controls (HC), to investigate enterotype associations with CHB, to assess the predictive capacity of enterosignatures for CHB phenotypes, and to determine causal relationships among gut microbiota, metabolites, and CHB. The cross-sectional investigation included 129 CHB patients and 58 HC, with fecal samples analyzed by 16S rRNA gene sequencing of the V3-V4 region. Significant differences in α-diversity and β-diversity (
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