ArticleJournal of International Society of Preventive & Community Dentistry
GCF NLRP3 as a Biomarker for Assessing Endodontic Treatment Outcomes in Symptomatic Irreversible Pulpitis: A Comparative Nonrandomized, Observational Cross-Sectional Study.
Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom-Based Classification.International endodontic journal · 2026Review
- Ultrasensitive multiplex salivary cytokine profiling reveals distinct immune signatures in dental caries.BDJ open · 2026Article
- Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.Frontiers in cell and developmental biology · 2026Review
- The Role of Inflammasomes in Chronic Oral Inflammatory Disease and Oral Cancer: A Narrative Review.Dentistry journal · 2025Review
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Authors and funding
6 authors.
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Abstract
Aim: Biomarker-based evaluation of endodontic outcomes offers an objective alternative to traditional clinical assessments. The human nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing-3 (NLRP3) inflammasome is emerging as a potential indicator in inflammatory dental conditions. The aim was to correlate changes in pain levels with gingival crevicular fluid (GCF) levels of the NLRP3 inflammasome in patients with symptomatic irreversible pulpitis (SIP), before and after nonsurgical endodontic treatment. Materials and Methods: This nonrandomized matched comparative study included 15 SIP patients (45 teeth: involved, adjacent, and contralateral) and 15 healthy controls (15 teeth). GCF samples were analyzed via enzyme-linked immunosorbent assay. Pain was assessed using the Heft Parker visual analog scale (HP-VAS). Data were analyzed using linear mixed models, the Wilcoxon signed-rank test, and the Spearman correlation. Results: Baseline GCF-NLRP3 levels were significantly higher in SIP-affected teeth (4.33 ± 0.98 ng/mL) than in controls (1.34 ± 0.45 ng/mL; Conclusion: GCF-NLRP3 levels can serve as a reliable biomarker for evaluating endodontic treatment outcomes in SIP, reflecting both local inflammation and patient-reported pain. Integrating GCF-NLRP3 monitoring may enhance the diagnostic accuracy and inform treatment planning. Future studies should assess longitudinal trends and therapeutic thresholds. GCF-NLRP3 could be a promising biomarker for assessing the outcome of endodontic treatment. This finding opens up new possibilities for improving the efficacy of endodontic procedures and, ultimately, patient care. Clinical Trial Registration: The clinical study was registered under the clinical trial registry-India www.ctri.nic.in (CTRI/2023/07/055526) on July 24, 2023. The supporting document can be produced through requisition mail to the corresponding author.
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