ArticleBreast care (Basel, Switzerland)2026
Investigation of Factors Affecting Histopathological Upgrade in Breast Papillary Lesions: A Single-Center Study.
Article in Breast care (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Breast papillary lesions are uncommon but clinically important due to their potential for histological upgrade. This study aimed to determine the factors that may influence histopathological upgrade in breast papillary lesions. Methods: A retrospective review was conducted of female patients who underwent surgery for papillary lesions at Erciyes University Medical Faculty Hospital from 2010 onward. Upgrade was defined as a benign/low-risk lesion on biopsy found to be high risk or malignant after excision; downgrade referred to the opposite scenario. Statistical analyses were performed using SPSS 22.0 (chi-square test, Results: Among 199 patients (median age: 53 years), 46 (23.1%) experienced histopathological upgrade and 13 (6.5%) had a downgrade. Upgrade was significantly associated with menopausal status ( Conclusions: In breast papillary lesions, menopause, certain comorbidities, and specific radiological factors (such as BI-RADS category and calcifications) may increase the risk of histopathological transition. These findings underscore the importance of a multidisciplinary approach in diagnosing and managing intraductal papillomas. Larger scale studies could further refine risk stratification, potentially reducing unnecessary surgeries while facilitating earlier identification of high-risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.