Evidence map›Paper›PMID 41244605›Full record

ArticleBiometrika2025

On the asymptotic validity of confidence sets for linear functionals of solutions to integral equations.

E Smucler, J M Robins, A Rotnitzky

Abstract read
In one paragraph

Article in Biometrika, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Simplifying debiased inference via automatic differentiation and probabilistic programming.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2026
    Article
  2. Elastic integrative analysis of randomised trial and real-world data for treatment heterogeneity estimation.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

E SmuclerGlovo, Carrer de Ramon Llull 110, Barcelona 08005, Spain.ORCID https://orcid.org/0000-0002-7600-4222
J M RobinsDepartment of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenuue, Boston, Massachusetts 02115, USA.
A RotnitzkyDepartment of Biostatistcs, University of Washington, 3980 15th Avenue NE, Seattle, Washington 98195-1617, USA.ORCID https://orcid.org/0000-0001-7917-0405

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
STATISTICAL ISSUES IN AIDS RESEARCHR37AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI JAMES P HUGHES · 1999 to 2026
$9.8M
Statistical Methods for Incorporating Machine Learning Tools in Inference and Large-Scale Surveillance using Electronic Medical Records DataR01HL137808 · NHLBI · UNIVERSITY OF WASHINGTON · PI CARONE, MARCO · 2019 to 2023
$2.4M
NHLBI NIH HHS R01 HL137808NIAID NIH HHS R37 AI029168NIAID NIH HHS UM1 AI068635
6 · The paper itself

Abstract

This paper examines the construction of confidence sets for parameters defined as linear functionals of a function of [Formula: see text] and [Formula: see text] whose conditional mean given [Formula: see text] and [Formula: see text] equals the conditional mean of another variable [Formula: see text] given [Formula: see text] and [Formula: see text]. Many estimands of interest in causal inference can be expressed in this form, including the average treatment effect in proximal causal inference and treatment effect contrasts in instrumental variable models. We derive a necessary condition for a confidence set to be uniformly valid over a model that allows for the dependence between [Formula: see text] and [Formula: see text] given [Formula: see text] to be arbitrarily weak. We show that, for any such confidence set, there must exist some laws in the model under which, with high probability, the confidence set has a diameter greater than or equal to the diameter of the parameter's range. In particular, consistent with the weak instrument literature, Wald confidence intervals are not uniformly valid over the aforementioned model when the parameter's range is infinite. Furthermore, we argue that inverting the score test, a successful approach in that literature, generally fails for the broader class of parameters considered here. We present a method for constructing uniformly valid confidence sets when all variables, but possibly [Formula: see text], are binary, discuss its limitations and emphasize that developing valid confidence sets for the class of parameters considered here remains an open problem.

Indexed as

Causal inferenceConfidence setInstrumental variableIntegral equationProximal causal inferenceWeak instrument

Identifiers

PMID41244605
PMCPMC12614171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.