Evidence map›Paper›PMID 41244583›Full record

ArticleiScience2025

Dicer is essential for proper maturation, composition, and function in the postnatal retina.

Seoyoung Kang, Daniel Larbi, Eik Bruns, Konstantin Hahne, Alireza Khodadadi-Jamayran, Chaitra Sreenivasaiah, Mariana Lima Carneiro, Monica Andrade, Khulan Batsuuri, Shaoheng Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Seoyoung KangDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Daniel LarbiDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Eik BrunsDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Konstantin HahneDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA.
Chaitra SreenivasaiahApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA.
Mariana Lima CarneiroDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Monica AndradeDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Khulan BatsuuriDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Shaoheng ChenDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Julia JagerDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.
Suresh ViswanathanIndiana University School of Optometry, Bloomington, IN, USA.
Brian Stewart ClarkJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences and Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Stefanie Gabriele WohlDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY, USA.

Funding

The Role of Retinal Progenitor microRNAs for Late-stage Progenitor Cell State and Muller Glia ReprogrammingR01EY032532 · NEI · STATE COLLEGE OF OPTOMETRY · PI Stefanie G Wohl · 2022 to 2026
$2.0M
Regulation of Retinal Development by RNA moleculesR01EY035381 · NEI · WASHINGTON UNIVERSITY · PI Brian S Clark · 2024 to 2026
$1.4M
Short-term Training Students in Health Professional SchoolsT35EY020481 · NEI · STATE COLLEGE OF OPTOMETRY · PI Stewart Allen Bloomfield · 2010 to 2026
$780k
NEI NIH HHS R01 EY032532NEI NIH HHS R01 EY035381NEI NIH HHS T35 EY020481
6 · The paper itself

Abstract

The impact of Dicer/miRNAs during postnatal retinogenesis is unknown. This study aimed to deplete Dicer in postnatal retinal progenitor/precursor cells (RPCs/PCs) and to evaluate the structure and function of the adult Dicer-cKO retina using optical coherence tomography (OCT), electroretinography (ERG), and histology. We found impaired rod function, a significantly reduced number of rod bipolar cells and their associated functions, a decreased Müller glia population, and an increased population of HuC/D + Pax6/+ amacrine cells in the adult Dicer-cKO retina. Transcriptional analyses conducted in one-week-old mice showed early alterations in mRNA and miRNA levels. Single-cell RNA sequencing and initial histological analysis in young mice revealed a delay in differentiation/incomplete maturation, as indicated by an enlarged progenitor/precursor population at young ages that persists into adulthood. This suggests that Dicer/miRNAs in late RPC/PCs are essential for the proper formation and maturation of late RPC progenies and may also play a role in regulating cell state.

Indexed as

cell biologydevelopmental biologyMolecular biologyNeuroscience

Identifiers

PMID41244583
PMCPMC12616091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.