Evidence map›Paper›PMID 41244563›Full record

ArticleiScience2025

Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity.

Yuangao Xu, Tamar Kapanadze, Svenja Gaedcke, Adan Chari Jirmo, Stefan Sablotny, Frauline Nicole Schroth, Susanne Hille, Oliver J Müller, Matthias Lochner, Hermann Haller and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuangao XuVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Tamar KapanadzeVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Svenja GaedckeDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, 30625 Hannover, Germany.
Adan Chari JirmoDepartment of Pediatric Surgery, Hannover Medical School, 30625 Hannover, Germany.
Stefan SablotnyVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Frauline Nicole SchrothVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Susanne HilleDepartment of Internal Medicine V, University Hospital Schleswig-Holstein, University of Kiel, 24105 Kiel, Germany.
Oliver J MüllerDepartment of Internal Medicine V, University Hospital Schleswig-Holstein, University of Kiel, 24105 Kiel, Germany.
Matthias LochnerInstitute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research Braunschweig and the Hannover Medical School, 30625 Hannover, Germany.
Hermann HallerMDI Biological Laboratory, Bar Harbor, ME, USA.
Kai Schmidt-OttDepartment of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Jaba GamrekelashviliVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Florian P LimbourgVascular Medicine Research, Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocyte heterogeneity and plasticity create a spectrum of phagocytes essential for innate immune functions, which is partially regulated by Notch signaling. Using systematic monocyte subset analysis in different compartments, we here confirm that monocyte heterogeneity extends beyond the Ly6C

Indexed as

cell biologImmunologymolecular biology

Identifiers

PMID41244563
PMCPMC12613001

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.