ArticlePakistan journal of medical sciences2025
Exploring the significance of GNG11, LPAR1, and AGTR1 in early diagnosis and prognosis of cervical cancer: A correlative analysis with clinical characteristics.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the significance of G-protein gamma subunit 11 (GNG11) expression in the diagnosis and prognosis of cervical cancer (CC). Methodology: This was a retrospective study. Differentially expressed genes in CC were retrieved from the Gene Expression Omnibus (GEO). A cohort of 68 CC patients from General Hospital of Ningxia Medical University Cancer Hospital was enrolled in the study from March 2021 to March 2024. Immunohistochemistry was employed to evaluate the expression levels of G-protein subunit γ 11 (GNG11), lysophospholipid receptor 1 (LPAR1), and angiotensin II receptor 1 (AGTR1) in cancerous and pericancerous tissues of CC patients. The correlations between the positive expressions of GNG11, LPAR1, or AGTR1 and the clinicopathological parameters of CC patients were analyzed. Results: A significant correlation was observed between low positive expression of GNG11 and tumor size ( Conclusion: The positive expression level of GNG11 is intricately linked to the early diagnosis and prognosis of CC, underscoring its potential as a significant diagnostic and prognostic indicator.
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