ArticlePakistan journal of medical sciences2025
The impact of duration below target mean arterial pressure value on mortality in critically ill patients.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- HeLP-BAG score: a novel data-driven scoring system for predicting post-operative 30-day mortality using 24-hour preoperative data.BMC anesthesiology · 2026Article
- Delta MEWS combined with SpOFrontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Literature lacks exploration of how the duration of low mean arterial pressure (MAP) affects mortality. This study aimed to determine whether the duration of MAP below 65 mmHg is associated with mortality in critically ill patients (CIPs). Methodology: A prospective observational study was conducted with patients who were admitted to the emergency department (ED) from July 1 to December 31, 2023, with a follow-up in the ED critical care unit for at least six hours. The average MAP and the total duration that the MAP remained below 65 mmHg (ΔtMAP<65) during this period were calculated. Results: In the study with 103 CIPs, ΔtMAP<65 was significantly higher in patients who died within 48 hours (247 [210-300] vs. 90 [30-135]) (p<0.001). ΔtMAP<65 was also significantly higher in patients who died within 30 days (195 [150-270] vs. 45 [15-75]) (p<0.001). Average MAP and ΔtMAP<65 highly predict 48 hours mortality, with AUC values of 0.887 and 0.957, respectively. ΔtMAP<65 for ≥180 minutes increased the risk of 48 hours mortality 173.25 (36.58-820.40) times. Average MAP and ΔtMAP<65 predicted 30 days mortality with AUC values of 0.890 and 0.963, respectively. ΔtMAP<65 for ≥135 minutes increased 30 days mortality 166.66 (20.78-1336.66) times. Conclusions: This study shows that the duration of MAP below 65 mmHg is associated with mortality in CIPs. When ΔtMAP<65, lasting over 135 minutes significantly increases the 30 days mortality risk. If it exceeds three hours, the 48 hours mortality risk also rises substantially. Monitoring cumulative hypotension duration in critical care may enhance survival through earlier interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.