Evidence map›Paper›PMID 41244504›Full record

ArticleACS omega2025

Physical and Chemical Modifications of Polymeric Surfaces to Enhance Epithelial Cell Adhesion.

Laura M S Santos, Jonathas M Oliveira, Artur F Sonsin, Sendy M S Nascimento, Vitor M L Fonseca, Juliane P Silva, Cléber R Mendonça, Alcenísio J Jesus-Silva, Emiliano Barreto, Eduardo J S Fonseca

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura M S SantosOptics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), 57072-970 Maceio, Alagoas, Brazil.ORCID https://orcid.org/0000-0001-8145-2110
Jonathas M OliveiraFederal Institute of Alagoas (IFAL), 57230-000 Coruripe, Alagoas, Brazil.
Artur F SonsinOptics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), 57072-970 Maceio, Alagoas, Brazil.
Sendy M S NascimentoOptics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), 57072-970 Maceio, Alagoas, Brazil.
Vitor M L FonsecaLaboratory of Cell Biology, Institute of Biological Sciences and Health, Federal University of Alagoas (ICBS/UFAL), 57072-970 Maceio, Alagoas, Brazil.
Juliane P SilvaLaboratory of Cell Biology, Institute of Biological Sciences and Health, Federal University of Alagoas (ICBS/UFAL), 57072-970 Maceio, Alagoas, Brazil.
Cléber R MendonçaInstitute of Physics of São Carlos, University of São Paulo, CP 369, 13560-970 São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6672-2186
Alcenísio J Jesus-SilvaOptics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), 57072-970 Maceio, Alagoas, Brazil.
Emiliano BarretoLaboratory of Cell Biology, Institute of Biological Sciences and Health, Federal University of Alagoas (ICBS/UFAL), 57072-970 Maceio, Alagoas, Brazil.
Eduardo J S FonsecaOptics and Nanoscopy Group, Institute of Physics, Federal University of Alagoas (UFAL), 57072-970 Maceio, Alagoas, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In tissue engineering, 3D scaffolds and chemical treatments are often used to provide a cell-friendly surface that improves cell adhesion and tissue growth. Indeed, cell adhesion can be regulated through physicochemical modifications of the substrate surface, including wettability, surface charge, and roughness. In this work, we present the synthesis, characterization, and cytocompatibility analysis of photoresins suitable for fabricating cell scaffolds via two-photon polymerization. Furthermore, we demonstrate a simple surface treatment method that promotes cell adhesion. This method alters the surface charge of the polymer and enhances the adhesion of epithelial cells. Our results indicate an efficient approach to modifying the surface of biocompatible polymer scaffolds with the purpose of enhancing the performance of cell functions that are suitable for tissue engineering and regenerative medicine.

Identifiers

PMID41244504
PMCPMC12612894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.