ArticleACS omega2025
Synthesis, Incorporation, and Translation Properties of Threose Nucleic Acid Modified Trinucleotide Cap Analogs.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
Enhancing protein translation remains a key objective in the continued development of mRNA-based therapeutics. One promising strategy involves the chemical modification of the 5' mRNA cap that is essential for RNA stability and translation initiation via eIF4E binding. Given its smaller size, nuclease stability, and unique 3' → 2' internucleotide linkage, we evaluated α-l-threofuranosyl nucleic acid (TNA) modification at the 5'-end of mRNA. TNA modified trinucleotide caps were synthesized and incorporated cotranscriptionally into several mRNAs using T7 polymerase with comparable full-length integrity, yield, and capping efficiency relative to reference cap
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Registered trials
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