ArticleACS omega2025
Aminoglycoside Drugs as Adjuvants to Enhance siRNA/mRNA Delivery by Lipid Nanoparticles.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleic acid drugs (such as siRNA and mRNA) hold broad prospects in disease treatment, but their clinical application is limited by low delivery efficiency, particularly due to insufficient lysosomal escape. This study aims to explore aminoglycoside small-molecule drugs as adjuvants to enhance the lysosomal escape efficiency of lipid nanoparticles (LNPs) for nucleic acid drug delivery, thereby improving therapeutic effects and providing new strategies for gene therapy. In this study, five FDA-approved aminoglycoside small molecules were selected as adjuvants to enhance the lysosomal escape of LNPs/siRNA and improve the siRNA delivery effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.