ArticleACS omega2025
Association Study of OATP1B3 Polymorphisms on Hepatic Uptake and Drug-Drug Interaction
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The OATP1B3 transporter is responsible for the hepatic uptake of multiple drugs and their metabolites. The single-nucleotide polymorphism (SNP) of OATP1B3 may be essential for interindividual variability in drug response. The distribution of nonsynonymous SNPs was defined within the Chinese Han population. The SNPs rs4149117 and rs7311358, corresponding to Ser112Ala and Met233Ile substitutions, were confirmed as the most frequent alleles. The effect of coding variants on the OATP1B3-based activity was assessed on HEK293A cells with stable gene expression. The uptake and inhibitory profiles of compounds were compared between variants and the wild-type (WT). Despite the altered transport velocity, the Michaelis-Menten constant for Ser112Ala, Met233Ile, and SM/AI (combined mutations) was comparable to that for the WT. Likewise, the inhibition of
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