ArticleACS omega2025
Combining Anion Transport and Phospholipid Binding for Improved Antibacterial Activity of Diamidocarbazoles.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lipophilic mono-guanidinesRSC advances · 2026Article
- An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery.Chemical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing bacterial resistance necessitates focusing on new antibiotic targets, such as bacterial membranes. Herein, heteroditopic diamidocarbazole-based receptors are shown to display significant antibacterial activity against Gram-positive bacteria by combining transmembrane anion transport with phosphatidylethanolamine binding, while remaining nontoxic for human red blood cells. Liposome-based and bacterial studies consistently support this dual mode of action, highlighting the potential of combining anion transport and lipid-binding properties as a strategy for the development of novel antibiotics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.