Evidence map›Paper›PMID 41244394›Full record

ArticleACS omega2025

Monosodium Glutamate Consumption Disrupts Vitamin B6 Status in Rat Kidney.

Manatsaphon Sukmak, Kanokwan Nahok, Chalongchai Chalermwat, Worachart Lert-Itthiporn, Atit Silsirivanit, Porntip Pinlaor, Apisit Chaidee, Sirirat Anutrakulchai, Somchai Pinlaor, Carolyn M Slupsky and 1 more

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manatsaphon SukmakDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Kanokwan NahokDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Chalongchai ChalermwatDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Worachart Lert-ItthipornDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Atit SilsirivanitDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID https://orcid.org/0000-0002-5777-3843
Porntip PinlaorChronic Kidney Disease Prevention in the Northeast of Thailand (CKDNET), Khon Kaen University, Khon Kaen 40002, Thailand.
Apisit ChaideeDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Sirirat AnutrakulchaiChronic Kidney Disease Prevention in the Northeast of Thailand (CKDNET), Khon Kaen University, Khon Kaen 40002, Thailand.
Somchai PinlaorDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID https://orcid.org/0000-0002-8187-7247
Carolyn M SlupskyDepartment of Nutrition and Department of Food Science & Technology, University of California, Davis, California 95616, United States.ORCID https://orcid.org/0000-0002-5100-1594
Ubon Cha OnDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID https://orcid.org/0000-0002-9909-8671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monosodium glutamate (MSG) is widely used as a food additive and flavor enhancer, but concerns have emerged regarding its potential effects on kidney function and vitamin B6 metabolism. This study investigated the impact of varying levels of dietary MSG intake on vitamin B6 status in a rat model. Male Wistar rats were divided into four groups and administered MSG in their drinking water at concentrations of 0, 0.5, 1.5, and 3.0 g % for 12 weeks. Three isoforms of vitamin B6, pyridoxal (PL), pyridoxal 5'-phosphate (PLP), and pyridoxic acid (PA), were measured in plasma, liver, kidney, and urine using HPLC-MS. Kidney metabolites were analyzed by

Identifiers

PMID41244394
PMCPMC12612882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.