Evidence map›Paper›PMID 41244322›Full record

ReviewCell insight2025

Mitochondrial cristae remodeling: Mechanisms, functions, and pathology.

Jianglong Yu, Yuanchun Luo, Jiacheng Lin, Zhuofan Li, Zheng Fang, He He, Chaojun Yan, Zhiyin Song

Abstract readReview
In one paragraph

Review in Cell insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  11. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  12. Review
  13. Article
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  15. Review
  16. Human lncRNAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Oxidative Stress andInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianglong YuCollege of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Yuanchun LuoCollege of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Jiacheng LinCollege of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Zhuofan LiCollege of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
Zheng FangCollege of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China.
He HeDepartment of Pathology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Chaojun YanNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, Hubei, China.
Zhiyin SongDepartment of Pathology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to physiological and stress cues. During remodeling, their number, length, width, lateral alignment, curvature/stiffness, and the geometry of crista junctions (CJs) can change. Depending on cellular context, cristae may increase in abundance, tighten or widen, and exhibit opening or closure of CJs, with corresponding effects on respiratory-chain organization and supercomplex assembly. Key regulators include OPA1 (and its proteolytic processing), the MICOS complex that scaffolds CJs, F

Indexed as

CardiolipinCristae remodelingF1Fo-ATP synthaseMICOS complexOPA1Oxidative phosphorylation

Identifiers

PMID41244322
PMCPMC12615294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.