ArticleJHEP reports : innovation in hepatology2025
TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Hypoxic Endothelial-Cell-Derived Exosomal lnc-DKK3 Reprograms Tumor-Associated Macrophages via USP47/PD-L1/RelA Axis to Promote Glioma Progression.Research (Washington, D.C.) · 2026Article
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21 authors.
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Abstract
Background & Aims: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer. Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), where they facilitate the malignant progression of ICC and reshape the TME. TATA-binding protein-associated factor 15 (TAF15), a protein that binds both DNA and RNA, plays a pivotal role in inflammatory signaling pathways and is abnormally expressed in TAMs in ICC. However, the specific function of TAF15 in ICC-associated macrophages remains to be elucidated. This study aimed to investigate the regulatory effect of TAF15 in ICC-associated macrophages on ICC progression. Methods: The expression pattern of TAF15 in macrophages was assessed using multicolor fluorescence in ICC mouse tissues and patient samples (n = 5 per group). TAF15 expression in THP-1 cells was manipulated using CRISPR-Cas9 technology. The polarization index of TAMs, as well as the impact of TAMs on ICC proliferation, was evaluated through Results: TAF15 is highly expressed in TAMs ( Conclusions: TAF15 has a pivotal role in ICC progression by affecting the phenotype of macrophages. Targeting TAF15 in TAMs emerges as a promising therapeutic strategy for the treatment of ICC. Impact and implications: Our study provides the first evidence that TATA-binding protein-associated factor 15 regulates tumor-associated macrophages polarization through the SOCS1/JAK2/STAT1 axis, unveiling a novel immunotherapeutic target for cholangiocarcinoma. The developed M2pep-LNP-siTAF15 nanodelivery system not only overcomes the challenge of targeted delivery, but its remarkable antitumor efficacy highlights strong potential for clinical translation. This work fundamentally advances our understanding of stromal-immune crosstalk in cholangiocarcinoma while offering a clinically actionable therapeutic strategy.
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