ArticleASM case reports2025
Pocapavir for neonatal enteroviral sepsis: limitations of rapid viral sequencing on treatment decisions.
Article in ASM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Background: Neonatal enterovirus infection can be severe and life-threatening, and there is ongoing interest in the development of antiviral compounds; however, their clinical efficacy has not been definitively proven. Case Summary: We describe a case of neonatal enterovirus infection treated with the investigational therapeutic pocapavir, a viral capsid inhibitor. We describe the medical decision-making regarding the choice to offer pocapavir therapy. Because of clinical uncertainty about whether pocapavir contributed to clinical improvement, we performed sequencing of the viral genome and modeled the pocapavir pocket-binding site for evidence of genetic and protein changes before or after the initiation of pocapavir that might confer antiviral resistance. Conclusion: This case and our findings reveal the challenges in interpreting sequence analysis of clinical enterovirus isolates to inform clinical decision-making regarding the use of pocapavir for the treatment of neonatal enterovirus.
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Registered trials
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