SynthesisFrontiers in pediatrics2025
Long term endocrine issues in adults born prematurely: a systematic review.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Patients in Every Practice: Health Status and Health Experiences of an International Sample of Adults Born Preterm.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prematurity is a risk factor for chronic disease later in life. According to figures in Ireland, preterm births represent 7% of all births which presents a significant issue for adult healthcare resources. This systematic review synthesised the evidence on long-term endocrine related outcomes for adults who were born prematurely. Methods: A systematic review was conducted by searching the official databases PubMed and Web of Science. Studies were included in the review based on the criteria that they investigated an endocrine outcome in adulthood in the following categories: issues of the hypothalamic-pituitar Results: The search yielded 1,814 studies and after removal of duplicates, 1,584 papers entered screening. 65 full texts were reviewed, after inclusion and exclusion criteria was applied, 27 studies were used for data extraction. Results revealed that being born premature was a significant risk factor for a myriad of endocrine issues in later life. Reduced height, dysfunction of the HPA axis, lower fertility rates, lower bone mineral density and increased odds of hypothyroidism were all outcomes that were associated with preterm birth. Cardiometabolic related outcomes formed the bulk of our data (11/27); these studies found associations between prematurity and increased risk of diabetes, decreased insulin sensitivity, higher body fat percentage and dyslipidaemia. Discussion: This review highlighted that prematurity is associated with long term endocrine dysfunction in multiple domains. It provided a large set of data demonstrating this association across the various endocrine pathologies relating to bone, thyroid, growth, reproduction and metabolism. This highlights the necessity of long term follow up into adulthood for individuals born preterm.
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